Many of the centers are in Macy's department stores. The store provides a specially designed space with offices, a lounge and classrooms, to create a comfortable setting where members can relax and meet people with similar interests. Additional programs are offered in other community locations.

Local sponsors such as health care institutions, nonprofit agencies, department stores, banks, businesses, foundations and individuals provide financial support. An OASIS director manages each center with assistance from staff and member volunteers.

OASIS is nationally sponsored by Federated Department Stores and BJC HealthCare.